The active ingredient of Duphalac® is lactulose, a disaccharide synthesized from lactose. Lactulose is a synthetic sugar, which does not occur naturally and cannot be degraded by animal or human enzymes. Lactulose is also referred to as an NDO (non-digestible oligosaccharide) and reaches the colon unchanged with only few available calories – 13kcals per 20ml (13.34g) dose. Here it is degraded by speciﬁc bacteria and broken down into low-molecular weight organic acids, essentially lactic, acetic, butyric and propionic acids. Thus, the intestinal contents are acidiﬁed and the osmotic pressure and the ﬁlling volume in the colon are increased, it makes the stool softer and easier to pass, by drawing water into the bowel. It is not absorbed into your body.
- Oral solution, a clear viscous liquid, colourless to brownish yellow.
- Oral solution flavoured with plum aroma, a clear, viscous liquid, colourless to brownish yellow.
- Powder for oral administration, white to almost white, crystalline powder.
1.Data on File, Duphalac® (lactulose), CCDS, dated 15th July 2013.