How can I take Duphalac if I’m constipated?1

The lactulose solution may be administered diluted or undiluted. A single dose of lactulose should be swallowed in one and should not be kept in the mouth for an extended period of time. The posology should be adjusted according to the individual needs of the patient.

In case of single daily dose, this should be taken at the same time, e.g. during breakfast. During the therapy with laxatives it is recommended to drink sufficient amounts of fluids (1.5 – 2 litres, equal to 6-8 glasses) during the day.

Duphalac oral powder can be taken from a spoon or tipped directly onto the tongue and then washed down with a drink of water or fluid. The crystals may also be sprinkled on food or mixed with water or fluids before swallowing; disperse the powder through the fluid while stirring.

Dosing in constipation or where a soft stool is considered of medical benefit: Lactulose may be given as a single daily dose or in two divided doses, using the measuring cup. After a few days the starting dosage may be adjusted to the maintenance dose based upon treatment response. Several days (2-3 days) of treatment may be needed before treatment effect occurs.

 

 

Starting dose daily

Maintenance dose daily

Starting dose daily

Maintenance dose daily

Adults and adolescents

15 - 45 ml

15 - 30 ml

10 - 30 grams
(1 - 3 sachets)

10 - 20 grams
(1 - 2 sachets)

Children
(7 - 14 years)

15 ml

10 - 15 ml

10 grams
(1 sachet)

7 - 10 grams
(3/4 - 1 sachet)

Children
(1 - 6 years)

5 - 10 ml

5 - 10 ml

3 - 7 grams
(1/3 - 2/3 sachet)

3 - 7 grams
(1/3 - 2/3 sachet)

Infants under 1 year

up to 5 ml

up to 5 ml

up to 3 grams
(1/3 sachet)

up to 3 grams
(1/3 sachet
)

Trademark oral solution

Trademark oral powder

Starting dose daily

Maintenance dose daily

Starting dose daily

Maintenance dose daily

Adults and adolescents

15 - 45 ml

15 - 30 ml

10 - 30 grams (1 - 3 sachets)

10 - 20 grams (1 - 2 sachets)

Children (7 - 14 years)

15 ml

10 - 15 ml

10 grams (1 sachet)

7 - 10 grams (3/4 - 1 sachet)

Children (1 - 6 years)

5 - 10 ml

5 - 10 ml

3 - 7 grams (1/3 - 2/3 sachet)

3 - 7 grams (1/3 - 2/3 sachet)

Infants under 1 year

up to 5 ml

up to 5 ml

up to 3 grams (1/3 sachet)

up to 3 grams (1/3 sachet)

References:
1. Data on File, Duphalac® (lactulose), CCDS, dated 15th July 2013.