Safety1, 12


Duphalac® has an enviable track record of tolerability and safety in over 50 years of clinical use in constipation over all age groups. This has been confirmed by large numbers of clinical studies with thousands of constipated patients worldwide.

At the beginning of treatment, flatulence may occur. As a rule it disappears after a few days. When dosages higher than instructed are used, abdominal pain and diarrhoea may occur. In such a case the dosage should be decreased.

1. Data on File, Duphalac® (lactulose), CCDS, dated 15th July 2013.
12. Tack J et al, diagnosis & treatment of chronic constipation-European perspective, Neurogastroenterol Motil (2011) 23, 697-710