Connolly P, Hughes IW, Ryan G. Comparison of ‘Duphalac’ and ‘irritant’ laxatives during and after treatment of chronic constipation: a preliminary study. Curr Med Res Opin. 1975;2(10):620-625.
Schuster-Wolff-Bühring R, Fischerac L, Hinrichsab J. Production and physiological action of the disaccharide lactulose. Int Dairy J. 2010;20(11):731-741.
Schumann C. Medical, nutritional and technological properties of lactulose. An update. Eur J Nutr 2002; 41(1): 17-25.
Company Core Data Sheet. Lactulose. Abbott. January 2023.
IQVIA MIDAS database Q1 2023 Release.
Pranami D, Sharma R, Pathak H. Lactulose: a prebiotic, laxative and detoxifying agent. Drugs Ther Perspect 2017; 33: 228-33.
Company Core Data Sheet. Duphaplus. Abbott. August 2019.
Werth BL, Williams KA, Fisher MJ et al. Defining constipation to estimate its prevalence in the community: results from a national survey. BMC Gastroenterology. 2019;19(75):1-7.
Gibson GR, Hutkins R, Sanders ME et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology, 2017;14:491-502.
Gallegos-Orozco JF, et al. Chronic constipation in the elderly. Am J Gastroenterol. 2012;107:18–25.
Mugie SM, et al. Epidemiology of constipation in children and adults: A systematic review. Best Pract Res Clin Gastroenterol. 2011 Feb;25(1):3-18.
Lewis SJ, et al. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997 Sep;32(9):920-4.
Devanarayana, NM and Rajindrajith S, Association between Constipation and Stressful Life Events in a Cohort of Sri Lankan Children and Adolescents. J Trop Ped. 2010;56(3):144-8.
Healthy bowel guide: Information for patients. Central and North West London NHS Foundation Trust. April 2015.
Arnaud MJ. Mild dehydration: a risk factor of constipation? Eur J Clin Nutr. 2003;57(2):S88-S95.
Hayat U, et al. Chronic constipation: Update on management. Clev Clin J Med. 2017;84(5):397-408
Tabbers MM, DiLorenzo C, Berger MY et al. Evaluation and Treatment of Functional Constipation in Infants and Children: Evidence-Based Recommendations From ESPGHAN and NASPGHAN. JPGN. 2014;58: 258-74.
Rajindrajith S, Devanarayana NM, Constipation in Children: Novel Insight Into Epidemiology, Pathophysiology and Management. J Neurogastroenterol Motil. 2011;17(1):35-47.
Trottier M, Erebara A, Bozzo P. Treating constipation during pregnancy. Canadian Family Physician. 2012; 58(8): 836-8.
Hejl M, Kamper J, Ebbesen F et al. Infantile constipation and Allomin-lactulose. Treatment of constipation in infants fed with breast-milk substitutes. A controlled clinical investigation of 2% and 4% Allomin-lactulose. Ugeskr Laeger 1990; 152: 1819-22.